![]() ![]() ![]() We further observed that TKI-resistant HCC exhibits an immune-evasive microenvironment, characterized by decreased CD8 + T cell and dendritic cell infiltration. In the present study, we first explored the therapeutic effect of anti-PD-1 immunotherapy in TKI-resistant HCC and successfully validated the putative cross-resistance to immunotherapy after TKI treatment. However, evidence from clinical trials suggests that the response to immunotherapy following TKI treatment is often compromised in TKI-resistant HCC as compared with treatment-naïve HCC, indicating a potential cross-resistance to immunotherapy, which impedes the optimal therapeutic effect of the second-line immunotherapies. ![]() Clinical practice guideline for HCC includes the management of the second-line immunotherapies after patients become unresponsive to first-line targeted therapies using tyrosine kinase inhibitors (TKI), which is expected to generate optimal therapeutic effect due to the distinct mechanism of action between TKIs and immunotherapies. Woody Woodburn writes a weekly column for The Star and can be contacted at His books are available at therapy is the current standard of care for unresectable advanced hepatocellular carcinoma (HCC), the most malignant form of liver cancer. This was on display last Sunday evening when he was inducted into the Ventura College Hall of Fame. Truth is, Joey wasn’t the only one in attendance who teared up during his splendid acceptance speech - my rainbow briefly turned blurry. One more reason: hard as a gemstone externally, inside Joey can be a softie. It is not lip service: Joey and his lovely wife Olivia’s three sons - Andrew, Marcos and Eric - are straight-A students on top of being exceptional athletes. Here’s some more that puts Joey in my rainbow: he was a standout college student became a high school math teacher and now, as head coach of the VC men’s basketball team, stresses education to his players. Listed on the roster at 5-foot-10, Joey stood tall as a center afterward despite his heartbreak. And yet it wasn’t Joey’s fierceness and winning ways that painted him into my rainbow - it was his grace and character in defeat.Įspecially, I remember the second state championship game loss by two points on a night the basket had a lid on it whenever Joey shot the ball. Not only did the Santa Paula native get floor burns diving for loose balls, he gave the hardwood skin-and-bone burns. Joey exemplified Coach Phil Mathew’s “We Play Hard” motto. More: Coaches Raguse, James and Ramirez headline Ventura College's 13th Hall of Fame class Under Joey’s leadership as star point guard during the 1992-94 seasons, the Pirates had a combined record of 73-5 and played in back-to-back state championship games. This selection will come as a surprise only to those who never watched No. Arnold Palmer, who like Johnson always treated me like I wrote for the New York Times rather than a local paper, gets a Masters-jacket green shade.Īnd bright orange - the Ventura College Pirates’ shade - in my rainbow goes to Joey Ramirez. Magic Johnson, who I wrote more columns about during my span than any other athlete, gets the hue of Lakers gold. My personal rainbow, however, comes into ready focus - albeit with all shades of blue going to my idol and mentor, John Wooden. Furthermore, giving Bach a golden hue does not diminish Beethoven’s bright red, which in turn does not raise him above Mozart’s forest green.Īsk me to name my favorite/greatest/best athlete from my quarter century as a sports columnist and I would be flummoxed. That’s the beauty of my rainbow philosophy: there are always enough colors to satisfy the eye of each beholder. Oh, yes, between the honorary bookends I have also inserted a few friendly hues largely unique to my elite shelf: Ken McAlpine, Jeff McElroy, Roger Thompson and, naturally, Dallas Woodburn. More: A 'great' effort spreading 'goodness' Steinbeck, Hemingway, Twain and Shakespeare comprise my personal Mount Rushmore, but there is top-self space for Woolf, Austen, Angelou and Rowling as well. Instead of bestowing the crown of Favorite or Greatest or Best, far better to imagine a single shelf in a bookcase with room enough only for a narrow rainbow of volumes. ![]() Or, in the case above, a hue on the palette. Better to imagine a rainbow and give the human gods each a color. Best, favorite, greatest too often miss the mark. ![]()
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